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There is a ReadyNAS Hard Disk Compatibility List here:http://kb.netgear.com/app/answers/detail/a_id/20641/~/readynas-hard-disk-compatibility-list?cid=wmt_...
The drive ST6000VX0001 is not listed here as compatible for the RN4220 models. Now, that drive might still work just fine, but Netgear could deny you support (if you at some point need support) as you are using an unsupported drive.
