ReadyNAS 4312 Windows Server 2016 HyperV iSCSI LUN advice required

Hi,

I have a new ReadyNAS 4312 (rack) with 14TB avaialble storage.

A Windows Server 2016 Standard Hyper-V host

10GB connectivity between them.

What are safe iSCSI LUN and VHDX levels that I can be OK with.

I propose to build a Fileserver on the HOST with its System & Data VHDX files actually stored on a ISCSI LUN on the NAS using Micrososoft's iSCSI initiator.

Would a single 12TB LUN with say a 70GB VHDX (O/S) and a 10TB VHDX (data) be 'safe'

Or maybe a a smaller VHDX for data would be safer.

I don't want to oversize the LUN or VHDX for fear of corruption.

All suggestions welcome.

Andy.